04353888 is referenced by 363 patents and cites 3 patents.

Viable mammalian cells are encapsulated in a polymeric membrane to form microencapsulated beads ready for introduction into a host body. The polymeric membrane allows passage therethrough of cell substrates and secretions, but prevents passage of larger molecules such as proteinaceous antibodies. In this way viable cells secreting essential products such as pancreatic islet cells secreting insulin can be transplanted into a host, and be protected against the immune reactions of the antibodies of the host which would otherwise reject the foreign cells. The cells are encapsulated from suspension in a non-solvent such as PPG, by addition thereto of a solution of a polymer (e.g. an acrylic/methacrylic acid esters copolymer) in dimethylsulfoxide. The polymer precipitates onto the cells to encapsulate them, and the supernatants are removed.

Title
Encapsulation of live animal cells
Application Number
6/219238
Publication Number
4353888
Application Date
December 23, 1980
Publication Date
October 12, 1982
Inventor
Michael V Sefton
21 Prince Charles Dr., Toronto, Ontario
CA
Agent
Fleit & Jacobson
IPC
A61K 9/00
A61K 9/28
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