04335121 is referenced by 91 patents and cites 4 patents.

Compounds of the formula ##STR1## wherein R.sup.1 represents a fluoro-, chloro- or bromo-methyl group or a 2'-fluoroethyl group, R.sup.2 represents a group COR.sup.6 where R.sup.6 is a C.sub.1-3 alkyl group or OR.sup.2 and R.sup.3 together form a 16.alpha.,17.alpha.-isopropylidenedioxy group; R.sup.3 represents a hydrogen atom, a methyl group (which may be in either the .alpha.- or .beta.-configuration) or a methylene group; R.sup.4 represents a hydrogen, chlorine or fluorine atom; R.sup.5 represents a hydrogen or fluorine atom and symbol represents a single or double bond have good anti-inflammatory activity, particularly on topical applications.

The compounds of formula I are prepared by esterification, halogenation, reduction, deprotection and reaction at a 9,11-double bond to form a 9.alpha.-halo-11.beta.-hydroxy grouping.

Pharmaceutical compositions containing the compounds of formula I and methods for the use of the compounds are described and claimed.

Title
Androstane carbothioates
Application Number
6/234113
Publication Number
4335121
Application Date
February 13, 1981
Publication Date
June 15, 1982
Inventor
Christopher Williamson
Cobham
GB
Ian P Steeples
Ruislip Manor
GB
Brian M Bain
Chalfont St. Peter
GB
Gordon H Phillipps
Wembley
GB
Agent
Bacon & Thomas
Assignee
Glaxo Group
GB
IPC
A61K 31/56
C07J 7/00
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