04287184 is referenced by 38 patents.

Healing of a wound is accelerated by administering a new form of nerve growth factor having a molecular weight of about 116,000 and which is stable in dilute aqueous solutions. The nerve growth factor is obtained from mouse submandibular gland or mouse saliva. An extract of mouse submandibular gland or mouse saliva is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The pure nerve growth factor is obtained by subjecting the component rich in nerve growth factor to at least one additional chromatography step, usually two to four, to recover pure nerve growth factor having a molecular weight of about 116,000. The nerve growth factor is applied directly to the wound.

Title
Process for healing wounds
Application Number
854194
Publication Number
4287184
Application Date
September 19, 1979
Publication Date
September 1, 1981
Inventor
David M Young
Sherborn
MA, US
Agent
Marvin C Guthrie
Paul J Cook
Assignee
The Massachusetts General Hospital
MA, US
IPC
A61K 37/00
A61K 35/37
View Original Source