04285987 is referenced by 384 patents and cites 2 patents.

An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from the compartment, (2) a second wall positioned distant from the first wall, said second wall a microporous or hydrogel material that extends around the first wall, and (3) a distribution zone interposed between the first and second wall and initially housing a compound soluble in an external fluid that enters the system.

In operation, agent is dispensed from the system by fluid passing through the second wall into the zone from which fluid is further being imbibed through the first wall into the compartment forming a solution that is released through the passageway into the zone, and then through the second wall to the exterior of the system.

Title
Process for manufacturing device with dispersion zone
Application Number
953906
Publication Number
4285987
Application Date
November 1, 1979
Publication Date
August 25, 1981
Inventor
Felix Theeuwes
Los Altos
CA, US
Atul D Ayer
Mountain View
CA, US
Agent
Edward L Mandell
Paul L Sabatine
Assignee
Alza Corporation
CA, US
IPC
A61M 7/00
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