04256889 cites 4 patents.

Benzocycloheptapyridines with an imine bridge in the cycloheptane ring, derivatives and pharmaceutically acceptable salts thereof are useful as anxiolytics, antidepressants, anticonvulsants, muscle relaxants and in the treatment of mixed anxiety-depression, minimal brain dysfunction and extrapyramidal disorders such as Parkinson's disease. They are prepared, for example, by treatment of a benzo[5,6]cyclohepta[1,2-c]pyridin-11-one with ammonia to give the 11-imine, acylation of the imine, treatment of the protected imine with an alkyllithium to provide the 11-alkyl-11-acylamino compound, treatment with acid or base to cause ring closure to an 11-alkyl-6,11-acylimino compound followed by removal of the protecting group, either hydrolytically or hydrogenolytically.

Title
Process for the preparation of imino-bridged benzocycloheptapyridines
Application Number
959049
Publication Number
4256889
Application Date
November 13, 1979
Publication Date
March 17, 1981
Inventor
Daniel G Brenner
Medford
MA, US
Kenneth L Shepard
Ambler
PA, US
Agent
William H Nicholson
Mario A Monaco
Assignee
Merck & Co
NJ, US
IPC
C07D 471/18
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