04248882 is referenced by 14 patents and cites 8 patents.

A series of amino-and alkylamino-substituted spirohydantoins and pharmaceutically acceptable salts thereof useful as inhibitors of the enzyme aldose reductase and as therapeutic agents for the treatment of chronic complications associated with diabetes are disclosed. Preferred compounds include 6-chloro-8-amino-spiro[4H-2,3-dihydro-1-benzopyran-4,4'-imidazolidine]-2', 5'-dione, the 6-fluoro and 8-methylamino- analogs thereof and the corresponding dihydrobenzothiopyran analogs of these compounds. The optical isomers of these compounds having the 4S-configuration are especially preferred.

Title
Treating diabetes-associated complications with hydantoin amines
Application Number
6/120944
Publication Number
4248882
Application Date
February 12, 1980
Publication Date
February 3, 1981
Inventor
Rodney C Schnur
Noank
CT, US
Reinhard Sarges
Mystic
CT, US
Agent
Peter C Richardson
Charles J Knuth
Francis X Murphy
Assignee
Pfizer
NY, US
IPC
C07D 491/107
C07D 495/10
A61K 31/47
A61K 31/415
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