04241046 is referenced by 170 patents and cites 2 patents.

The disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, removing the organic solvent and suspending the resultant gel in water. The method of the invention is advantageous over prior art methods of encapsulating biologically active materials in that it provides a means for a relatively high capture efficiency of the material for encapsulation. The disclosure is also of intermediate compositions in the encapsulation method, the product vesicles, compositions including the product vesicles as an active ingredient and their use.

Title
Method of encapsulating biologically active materials in lipid vesicles
Application Number
881116
Publication Number
4241046
Application Date
November 30, 1978
Publication Date
December 23, 1980
Inventor
Francis C Szoka Jr
375 Leroy Ave., Buffalo, 14214
NY, US
Demetrios P Papahadjopoulos
78 Heathwood, Williamsville, 14221
NY, US
Agent
Kane Dalsimer Kane Sullivan and Kurucz
IPC
A01N 25/00
A61K 9/22
A01N 25/26
View Original Source