04232158 is referenced by 8 patents and cites 10 patents.

10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines, derivatives and pharmaceutically acceptable salts thereof are useful as antianxiety agents, as muscle relaxants and in the treatment of extrapyramidal disorders such as in Parkinson's disease. They are prepared by treatment of a 5H-dibenzo[a,d]cyclohepten-5-one with ammonia to give the 5-imine, acylation of the imine, treatment of the protected imine with an organolithium to provide the 5-substituted-5-acylamino compound, treatment with acid or base to cause ring closure to a 5-substituted-5,10-acylimino compound followed by removal of the protecting group, either hydrolytically or hydrogenolytically.

Title
10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines
Application Number
6/45494
Publication Number
4232158
Application Date
June 4, 1979
Publication Date
November 4, 1980
Inventor
Daniel G Brenner
Medford
MA, US
Kenneth L Shepard
Ambler
PA, US
Agent
William H Nicholson
Mario A Monaco
Assignee
Merck & Co
NJ, US
IPC
C07D 487/08
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