04230691 is referenced by 22 patents.

An antibody is prepared from a stable new form of nerve growth factor having a molecular weight of about 116,000. The pure nerve growth factor is obtained from an extract of mouse submandibular gland or mouse saliva which is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The component rich in nerve growth factor is subjected to at least one additional chromatography step, usually two to four, to obtain pure nerve growth factor. The pure nerve growth factor then is injected into the blood system of an animal to form the antibody which is recovered from the animal's blood serum.

Title
Nerve growth factor antibody and process
Application Number
5/908762
Publication Number
4230691
Application Date
May 23, 1978
Publication Date
October 28, 1980
Inventor
David M Young
Sherborn
MA, US
Agent
Thompson Birch Gauthier & Samuel
Assignee
The Massachusetts General Hospital
MA, US
IPC
A61K 37/02
C07G 7/00
A61K 39/00
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