04217898 is referenced by 124 patents and cites 9 patents.

A system is disclosed for delivering an active agent to a fluid environment of use. The system comprises a microporous reservoir, an active agent housed in the reservoir, a surface that defines an exposed area of the reservoir for releasing agent from the reservoir to the environment, and a wall impermeable to both fluid and agent that surrounds the remaining, unexposed surfaces of the reservoir. In operation, when the system is in the environment with the exposed surface presented to fluid, fluid enters the system through the exposed surface causing agent to diffuse from within the system, which agent is released from the exposed surface of the system to the environment at a controlled rate over time.

Title
System with microporous reservoir having surface for diffusional delivery of agent
Application Number
5/953907
Publication Number
4217898
Application Date
October 23, 1978
Publication Date
August 19, 1980
Inventor
Felix Theeuwes
Los Altos
CA, US
Agent
Thomas E Ciotti
Edward L Mandell
Paul L Sabatine
Assignee
Alza Corporation
CA, US
IPC
A61M 31/00
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