04180560 is referenced by 35 patents and cites 1 patents.

A novel spherical implant pellet containing estradiol, estradiol benzoate, or mixtures thereof as the sole active ingredients which exhibits a substantially constant drug release rate over a timer period and substantially abrupt termination of drug release at the end of the time period is prepared which has an inert spherical core of a diameter of about 2-10 mm and a uniform coating of about 0.05-1 mm completely covering the core, the coating comprising about 5-99% suitable carrier and 1-95% drug. A drug may be administered at a constant rate over a chosen period by implanting the novel pellet and the release is substantially abruptly terminated at the end of said period without removing the pellet.

Title
Inert core implant pellet
Application Number
572031
Publication Number
4180560
Application Date
May 5, 1978
Publication Date
December 25, 1979
Inventor
John S Kent
Palo Alto
CA, US
Martin Katz
Los Altos Hills
CA, US
Agent
Joseph I Hirsch
Tom M Moran
Assignee
Syntex Corporation
CA, US
IPC
A61K 9/24
A61K 9/22
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