04179337 is referenced by 1429 patents and cites 8 patents.

Polypeptides such as enzymes and insulin are coupled to polyethylene glycol or polypropropylene glycol having a molecular weight of 500 to 20,000 daltons to provide a physiologically active non-immunogenic water soluble polypeptide composition. The polyethylene glycol or polypropylene glycol protect the polypeptide from loss of activity and the composition can be injected into the mammalian circulatory system with substantially no immunogenic response.

Title
Non-immunogenic polypeptides
Application Number
381191
Publication Number
4179337
Application Date
July 28, 1977
Publication Date
December 18, 1979
Inventor
Nicholas C Palczuk
45 W. Franklin St., Bound Brook, 08805
NJ, US
Theodorus Van Es
313 Overbrook Rd., Piscataway, 08854
NJ, US
Frank F Davis
19 Farmingdale Rd., East Brunswick, 08816
NJ, US
Agent
Omri M Behr
IPC
A61K 37/48
A61K 37/26
C07G 7/02
C07G 7/00
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