04160020 is referenced by 248 patents and cites 1 patents.

An osmotic device is disclosed for delivering an active agent. The device comprises a wall surrounding a compartment with a passageway through the wall for releasing the agent. The wall comprises a material permeable to an external fluid and substantially impermeable to agent and at least one additional material independently selected from materials that impart stability to the wall, enhance the permeability of the wall to fluids, or aid in forming the wall. The compartment contains an agent that exhibits an osmotic pressure gradient across the wall against an external fluid, or the agent is mixed with an osmotically effective compound that exhibits an osmotic pressure gradient against the fluid. Agent is released from the device by fluid being imbided through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall, thereby producing a solution containing agent that is released through the passageway at a controlled rate over time.

Title
Therapeutic device for osmotically dosing at controlled rate
Application Number
634859
Publication Number
4160020
Application Date
December 27, 1977
Publication Date
July 3, 1979
Inventor
Felix Theeuwes
Los Altos
CA, US
Atul D Ayer
Mt. View
CA, US
Agent
Edward L Mandell
Thomas E Ciotti
Paul L Sabatine
Assignee
Alza Corporation
CA, US
IPC
A61K 9/44
A61K 9/24
A61M 31/00
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