04159345 is referenced by 53 patents and cites 3 patents.

An excipient for use in manufacture of tablets, capsules, powders, microgranules and granules which consists essentially of a microcrystalline cellulose having an average degree of polymerization of 60 to 375 and obtained through acid hydrolysis or alkaline oxidative degradation of a celulosic substance selected from linters, pulps and regenerated fibers, said microcrystalline cellulose being a white cellulosic powder having an apparent specific volume of 1.6 to 3.1 cc/g, a repose angle of 35.degree. to 42.degree., a 200-mesh sieve residue of 2 to 80% by weight and a tapping apparent specific volume of at least 1.4 cc/g and a pharmaceutical composition comprising a pharmaceutically active ingredient and the excipient. This excipient has improved flowability and moldability or compressibility whereby excellent pharmaceutical preparations may be easily provided. In addition, pharmaceutical compositions obtained using such excipient are excellent in various pharmaceutical characteristics such as rate of disintegration, rate of dissolution, etc.

Title
Novel excipient and pharmaceutical composition containing the same
Application Number
5/873990
Publication Number
4159345
Application Date
January 31, 1978
Publication Date
June 26, 1979
Inventor
Akimitsu Tamada
Nobeoka
JP
Tetuya Aoyagi
Nobeoka
JP
Kimihiko Takeo
Nobeoka
JP
Agent
Charles H Johnson
Assignee
FMC Corporation
PA, US
IPC
A61K 47/00
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