04141973 is referenced by 297 patents.

An ultra-pure, high molecular weight hyaluronic acid fraction which is characterized by the absence of significant cellular infiltration of the vitreous and anterior chamber, absence of significant flare in the aqueous humor, absence of significant haze or flare in the vitreous and absence of pathological changes to the cornea, lens, iris, retina, and choroid of the owl monkey eye when one milliliter of a 1% solution of the sodium salt thereof dissolved in physiological buffer is implanted in the vitreous replacing about one-half the existing liquid vitreous. This material is obtained from animal tissue containing hyaluronic acid by a process which comprises removing the blood from animal tissue containing hyaluronic acid, extracting hyaluronic acid therefrom, deproteinizing the hyaluronic acid extract, and removing any unidentified inflammation causing agents persent therein by treating the deproteinized hyaluronic acid extract at a pH of 6.0 - 7.0 with a volume of chloroform at least about equal to that of the deproteinized extract, to form a two-phase mixture which is then stirred, sufficiently to ensure intimate contact between said two phases, at about 15.degree. - 40.degree. C., followed by separating out and discarding the chloroform phase.

Title
Ultrapure hyaluronic acid and the use thereof
Application Number
623333
Publication Number
4141973
Application Date
October 25, 1977
Publication Date
February 27, 1979
Inventor
Endre A Balazs
Riverdale
NY, US
Agent
Hubbell Cohen Stiefel & Gross
Assignee
Biotrics
NY, US
IPC
C07G 3/00
A61K 31/70
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