04077407 is referenced by 226 patents and cites 22 patents.

An osmotic device for delivering an active agent is disclosed. The device is comprised of a wall surrounding a compartment and has a passageway through the wall for releasing the agent. The wall is formed of a multiplicity of materials comprising a material permeable to an external fluid and substantially impermeable to agent and at least one additional material selected from a material that imparts stability to the wall, enhances the permeability of the wall to fluids, or aids in forming the wall. The compartment comprises an active agent that exhibits an osmotic pressure gradient against an external fluid, or the agent is mixed with an osmotically effective compound that exhibits an osmotic pressure gradient against the fluid. Agent is released from the device by fluid being imbibed through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall, to produce a solution containing agent that is released through the passageway at a controlled and continuous rate over a prolonged period of time.

Title
Osmotic devices having composite walls
Application Number
5/634859
Publication Number
4077407
Application Date
November 24, 1975
Publication Date
March 7, 1978
Inventor
Atul D Ayer
Belmont
CA, US
Felix Theeuwes
Los Altos
CA, US
Agent
Edward L Mandell
Thomas E Ciotti
Paul L Sabatine
Assignee
Alza Corporation
CA, US
IPC
A61M 31/00
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