04031894 is referenced by 204 patents and cites 8 patents.

Method and therapeutic system in the form of a bandage that administer scopolamine base transdermally in an initial pulse of 10 to 200 .mu.g/cm.sup.2 of skin that quickly brings the concentration of scopolamine in the plasma to a level at which emesis and nausea are inhibited without intolerable side effects, followed by a substantially constant dosage in the range of 0.3 to 15 .mu.g/hr that holds said level. The bandage is a four-layer laminate of, from the top: a protective backing; a gelled, mineral oil-polyisobutene-scopolamine reservoir lamina that is the source of the constant dosage; a microporous membrane that controls the constant dosage rate; and a gelled, mineral oil-polyisobutene-scopolamine adhesive layer that is the source of the pulse dose and the means by which the bandage is attached to the skin.

Title
Bandage for transdermally administering scopolamine to prevent nausea
Application Number
547504
Publication Number
4031894
Application Date
September 7, 1976
Publication Date
June 28, 1977
Inventor
Jane Elizabeth Shaw
Atherton
CA, US
Santosh Kumar Chandrasekaran
Palo Alto
CA, US
John Urquhart
Palo Alto
CA, US
Agent
Edward L Mandell
Paul L Sabatine
Thomas E Ciotti
Assignee
Alza Corporation
CA, US
IPC
A61L 15/06
A61F 7/02
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