04024272 is referenced by 104 patents and cites 1 patents.

Tetracyclic compounds of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 each are H or alkyl, R.sup.5 is H, F, Cl, Br, CF.sub.3, OH, alkyl, alkoxy, NO.sub.2, NH.sub.2, alkylamino, dialkylamino or acylamino and X is O, S, SO, SO.sub.2, NH, N-alkyl or N-acyl, alkyl and alkoxy in each case being of 1-3 carbon atoms and acyl in each case being of 1-4 carbon atoms, with the proviso that when R.sup.5 is methoxy and X is a sulfur atom, R.sup.5 is in the 8- or 9-position only, and their physiologically acceptable acid addition salts, possess broad spectrum antibacterial activity, including tetracycline-resistant Gram-positive and Gram-negative organisms.

Title
Tetracyclic compounds
Application Number
5/607803
Publication Number
4024272
Application Date
August 26, 1975
Publication Date
May 17, 1977
Inventor
Joachim Gante
Darmstadt
DT
Helmut Wahlig
Darmstadt
DT
Rolf Bergmann
Darmstadt
DT
Rosmarie Steinigeweg
Darmstadt
DT
Rudolf Gottschlich
Darmstadt
DT
Jurgen Seubert
Darmstadt
DT
Richard Kirchlechner
Darmstadt
DT
Werner Rogalski
Darmstadt
DT
Agent
Millen & White
Assignee
Merck Patent Gesellschaft mit beschrankter Haftung
DT
IPC
C07D 335/16
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