04016880 is referenced by 108 patents and cites 7 patents.

Osmotically driven active agent dispenser for use in an aqueous environment that pumps a solution of active agent, such as a drug, at a predetermined, constant rate. The dispenser is in the form of a coated tablet comprising: a core of an osmotically effective active agent composition; and an inexpandable wall that encloses the core, has a controlled permeability to water and includes means, such as brittleness or sites of structural weakness, that is responsive to the pressure generated within the dispenser by imbibition of water from the environment by the core through the wall to form at least one, and usually many, passageways in situ in the wall through which the active agent composition in solution is pumped osmotically at a rate that is substantially dependent of the rate at which water is being imbibed into the dispenser.

Title
Osmotically driven active agent dispenser
Application Number
5/663665
Publication Number
4016880
Application Date
March 4, 1976
Publication Date
April 12, 1977
Inventor
Nalinkant C Damani
Sunnyvale
CA, US
Felix Theeuwes
Los Altos
CA, US
Agent
Edward L Mandell
Paul L Sabatine
Thomas E Ciotti
Assignee
Alza Corporation
CA, US
IPC
A61M 31/00
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