04008719 is referenced by 641 patents and cites 8 patents.

An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a lamina consisting of a material or of a multiplicity of materials to provide a laminated wall that is permeable to agents and maintains its integrity during the delivery of agent. The compartment contains an agent that is soluble in an external fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or the agent has limited solubility in the fluid and is mixed with an osmotically effective compound soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid. In operation, agent is released from the system by fluid being imbibed through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.

Title
Osmotic system having laminar arrangement for programming delivery of active agent
Application Number
5/654195
Publication Number
4008719
Application Date
February 2, 1976
Publication Date
February 22, 1977
Inventor
Atul D Ayer
Belmont
CA, US
Felix Theeuwes
Los Altos
CA, US
Agent
Thomas E Ciotti
Edward L Mandell
Paul L Sabatine
Assignee
Alza Corporation
CA, US
IPC
A61M 31/00
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