04008717 is referenced by 332 patents and cites 9 patents.

A small, portable, constant withdrawal device is connected to tubing, including a catheter, whose internal walls are coated with heparin. The catheter is inserted intravenously through a disposal needle into a subject such as a human being. The subject may then move about for a selected period when blood is being slowly withdrawn at a prescribed rate and collected in a container within a housing supporting the device. The collected blood may then be analyzed to permit the measurement of the integrated concentration of glucose, growth hormone or other material in blood. In addition, a portable microdiffusion chamber is incorporated between the indwelling catheter and the extra corporal tubing and is electrically connected through a sensor probe to an associated sensory responsive device. This permits continuous analysis of the withdrawn blood to determine the in vivo concentration of circulating concentrations of materials in the blood.

Title
System for continuous withdrawal and analysis of blood
Application Number
323985
Publication Number
4008717
Application Date
March 5, 1976
Publication Date
February 22, 1977
Inventor
Allen A Kowarski
Baltimore
MD, US
Agent
Cushman Darby & Cushman
Assignee
The Johns Hopkins University
MD, US
IPC
A61M 1/00
A61B 5/00
View Original Source