04004586 is referenced by 56 patents and cites 11 patents.

First and second sealed, sterile containers, having respectively communicating first and second fluid transfer tubes, the tubes having diaphragms occluding the bores thereof, may be connected together in sterile manner for the sterile transfer of the contents of one container to the other. To accomplish this, one point of a double-pointed, hollow spike is inserted into each of the bores of the fluid transfer tubes, at the free ends thereof, the spike being proportioned to tightly and sealingly fit into each bore of the fluid transfer tubes. Thereafter, the spike and that portion of the tubes extending from the diaphragms to the free ends thereof are sterilized. Then the points of the spike are moved to rupture the diaphragms, to open a flow channel, and the sterile contents are transferred. The fluid transfer tube of the container receiving the desired sterile contents is then resealed, prior to breaking sterility by opening the connection.

Title
Method and apparatus for sealed, sterile connection
Application Number
5/557853
Publication Number
4004586
Application Date
March 12, 1975
Publication Date
January 25, 1977
Inventor
Steven L Olson
Lake Zurich
IL, US
Thomas R Hektner
Wilmette
IL, US
John G Christensen
Prairie View
IL, US
Agent
Paul C Flattery
Garrettson Ellis
Assignee
Baxter Travenol Laboratories
IL, US
IPC
A61M 5/14
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