03946106 is referenced by 28 patents and cites 7 patents.

The present invention is concerned with a pharmaceutical delivery device comprising a biologically acceptable silicone polymer matrix having microsealed compartments of 10-200 microns throughout, wherein the microsealed compartments contain a pharmaceutical in a hydrophilic solvent system. The biologically acceptable silicone polymer matrix is formed by in situ cross linking of a liquid, biologically acceptable silicone polymer in an emulsion of pharmaceutical in the hydrophilic solvent system and liquid biologically acceptable silicone polymer. The biologically acceptable silicone polymer matrix is placed in a sealed or unsealed biologically acceptable polymer container. The rate of release of pharmaceutical is controlled by altering the solubility characteristics of the hydrophilic solvent system and/or the biologically acceptable polymer matrix, the rate of release being independent of time when the ratio of the partition coefficient of the pharmaceutical between the hydrophilic solvent system and biologically acceptable silicone polymer matrix to the solubility of the pharmaceutical in the hydrophilic solvent system is between 1 and 10.sup..sup.-4 ml/mcg.

Title
Microsealed pharmaceutical delivery device
Application Number
5/517454
Publication Number
3946106
Application Date
October 24, 1974
Publication Date
March 23, 1976
Inventor
Howard J Lambert
Deerfield
IL, US
Yie W Chien
Skokie
IL, US
Agent
John J McDonnell
Assignee
G D Searle & Co
IL, US
IPC
A61K 9/26
A61K 9/00
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