A polyplex of a double stranded RNA (dsRNA) and a polymeric conjugate consists of a linear polyethyleneimine (PEI) covalently linked to one or more polyethylene glycol (PEG) moieties. Each PEG moiety is conjugated via a linker to a targeting moiety capable of binding to a cancer antigen. Exemplary cancer antigens include epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2) and prostate surface membrane antigen (PSMA).

Title
POLYPLEX OF DOUBLE-STRANDED RNA AND POLYMERIC CONJUGATE
Application Number
16/297133
Publication Number
20190192563 (A1)
Application Date
March 8, 2019
Publication Date
June 27, 2019
IPC
A61K 45/06
A61K 47/60
A61K 47/59
C12N 15/117
A61K 35/14
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