The present invention concerns methods for detecting a nucleic acid comprising (i) contacting a solution comprising a first PNA having a first cross-reactive functional group with a substrate having a second PNA affixed thereto, the second PNA having a second first cross-reactive functional group, wherein the first PNA has a reporter molecule attached thereto and the first and second PNAs being complementary to different portions of a target DNA; (ii) contacting a sample suspected of containing the nucleic acid with the first and second PNAs; and (iii) determining the presence of the reporter molecule on the substrate.

Title
Cross-coupled peptide nucleic acids for detection of nucleic acids of pathogens
Application Number
13/592490
Publication Number
20120322053
Application Date
August 23, 2012
Publication Date
December 20, 2012
Inventor
Christopher Micklitsch
Rockville
MD, US
Daniel H Appella
Rockville
MD, US
IPC
C12Q 01/68
G01N 21/78
C12Q 01/70
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