The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFRα antagonist. The invention also provides antibodies that bind to human PDGFRα and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFRα, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.

Title
Methods of treating secondary bone tumors with antibodies against pdgfr alpha
Application Number
13/276358
Publication Number
20120034244
Application Date
October 19, 2011
Publication Date
February 9, 2012
Inventor
Nathan Graeme DOLLOFF
Morgantown
PA, US
Alessandro FATATIS
Penn Valley
PA, US
Nick LOIZOS
Staten Island
NY, US
Assignee
Imclone
IN, US
Philadelphia Health And Education Corporation D B A Drexel University College
PA, US
IPC
A61P 35/00
A61K 39/395
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