An influenza vaccine adjuvanted with a sub-micron oil-in-water emulsion elicits significantly higher immune responses in human pediatric populations. Compared to an existing unadjuvanted pediatric influenza vaccine, the adjuvanted vaccines provided herein can induce in children a longer persistence of high serum antibody titers and also longer seroconversion and seroprotection. The improvement in immune responses is seen for both influenza A virus and influenza B virus strains, but it is particularly marked for influenza B virus. Moreover, while the existing vaccine provides poor immunity in children after a single dose, the adjuvanted vaccine provides high seroprotection rates against the influenza A virus H3N2 subtype even after a single dose. Furthermore, the adjuvanted vaccine offers significantly better seroprotection against mismatched strains of influenza A virus.

Adjuvanted influenza vaccines for pediatric use
Application Number
Publication Number
Application Date
June 23, 2011
Publication Date
February 2, 2012
Michele Pellegrini
Nicola Groth
Audino Podda
Novartis Vaccines And Diagnostics
A61K 09/107
A61P 31/16
A61K 39/145
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