A pharmaceutical composition useful in the treatment or prevention of transgenic xenograft rejection comprising immunosuppressant compounds selected from the group consisting of an IL-2 transcription inhibitor and immunosuppressant compounds that immunosuppress for B-cell-mediated or antibody-mediated rejection of xenografts, and pharmaceutically acceptable diluents or carriers, and a method of preventing hyperacute rejection, reducing early graft damage, improving early xenograft function and promoting long term survival of said transgenic xenografts comprising the steps of i) contacting the body fluid removed from a human recipient with a xenoantigenic material which is bound to a biocompatible solid support, ii) reintroducing the treated body fluid into the recipient, and iii) treating the recipient with said pharmaceutical composition.

Title
Combinations of immunosuppressive agents for the treatment or prevention of graft rejections
Application Number
13/025347
Publication Number
20110142953
Application Date
February 11, 2011
Publication Date
June 16, 2011
Inventor
Paolo BRENNER
John WALLWORK
Peter John FRIEND
David James Graham WHITE
Guy TACCARD
Francoise RICHARD
Emanuele Luigi COZZI
Hendrik J SCHUURMAN
Charlestown
MA, US
IPC
A61P 37/06
A61K 38/13
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