The instant invention provides for substituted naphthyridine compounds that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.

Title
Inhibitors of akt activtiy
Application Number
11/921352
Publication Number
20100222321
Application Date
June 7, 2006
Publication Date
September 2, 2010
Inventor
Jiabing Wang
Chalfont
PA, US
Philip E Sanderson
Valley Forge
PA, US
Michael A Rossi
Limerick
PA, US
Kevin J Rodzinak
Schwenksville
PA, US
Jun Liang
Palo Alto
CA, US
Yiwei Li
San Diego
CA, US
Mark E Layton
Harleysville
PA, US
Michael J Kelly III
Wayne
PA, US
Essa H Hu
Camarillo
CA, US
Donna J Armstrong
Harleysville
PA, US
Agent
Merck
NJ, US
IPC
A61P 35/00
A61K 31/4709
A61K 31/517
A61K 31/5377
A61K 31/501
C07D 513/04
A61K 31/506
A61K 31/519
A61K 31/496
C07D 471/14
A61K 31/4375
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