This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Title
NOVEL DIAZABICYCLIC ARYL DERIVATIVES
Application Number
12/694952
Publication Number
20100130483 (A1)
Application Date
January 27, 2010
Publication Date
May 27, 2010
Inventor
Philip K Ahring
Ballerup
DK
Tino Dyhring Jørgensen
Ballerup
DK
Elsebet Øtergaard Nielsen
Ballerup
DK
Gunnar M Olsen
Ballerup
DK
Dan PETERS
Malmoe
SE
Agent
BIRCH STEWART KOLASCH & BIRCH
VA, US
Assignee
NeuroSearch
DK
IPC
A61P 5/00
A61P 15/00
A61P 15/06
A61P 11/06
A61P 1/12
A61P 9/10
A61P 21/00
A61P 3/04
A61P 25/16
A61P 25/18
A61P 25/24
A61P 25/28
A61P 25/00
C07D 243/10
A61K 31/551
View Original Source