This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

Title
DIAZABICYCLIC ARYL DERIVATIVES AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
Application Number
12/652512
Publication Number
20100130482 (A1)
Application Date
January 5, 2010
Publication Date
May 27, 2010
Inventor
Daniel B Timmerman
Ballerup
DK
Philip K Ahring
Ballerup
DK
Tino Dyhring Jørgensen
Ballerup
DK
Elsebet Østergaard Nielsen
Ballerup
DK
Gunnar M Olsen
Ballerup
DK
Dan Peters
Ballerup
DK
Agent
BIRCH STEWART KOLASCH & BIRCH
VA, US
IPC
A61P 25/24
A61P 25/18
A61P 25/30
A61P 25/28
C07D 243/10
A61K 31/5513
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