The present invention relates to methods of treating atherosclerosis, dyslipidemia, other cardiovascular diseases and related diseases, such as diabetes, using a serine palmitoyltransferase (SPT) inhibitor. The present invention also relates to pharmaceutical compositions and kits that comprise a serine palmitoyltransferase (SPT) inhibitor, optionally with another pharmaceutical agent.

Title
Imidazole-Based Hmg-Coa Reductase Inhibitors
Application Number
10/594348
Publication Number
20080027088
Application Date
March 21, 2005
Publication Date
January 31, 2008
Inventor
Mark D Rekhter
Carmel
IN, US
Tae Sik Park
Ann Arbor
MI, US
Robert L Panek
Ann Arbor
MI, US
Sotirios K Karathanasis
Carmel
IN, US
Reynold Homan
Ann Arbor
MI, US
Agent
Pfizer
CT, US
Assignee
Warner Lambert Company
IPC
A61P 03/10
A61P 03/04
A61K 31/505
A61K 31/47
A61K 31/455
A61K 31/405
A61K 31/351
A61K 31/201
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