Described are flexible, finite systems for the transdermal administration of scopolamine, comprising: (a) a polymer matrix comprising a polymer blend comprising (i) a non-functional acrylic-based polymer constituting at least about 60% by weight of the dry weight of the polymer matrix, and (ii) an amine-resistant capped silicone polymer constituting not more than about 30% by weight of the dry weight of the polymer matrix; and (b) scopolamine solubilized in the polymer matrix, wherein the flexible, finite system is substantially free of vinyl acetate and polar components. In some embodiments, the polymer matrix also comprises a non-polar penetration enhancer. Methods of making and using such flexible, finite systems also are described.

Title
Compositions and methods for delivery of amino-functional drugs
Application Number
11/710610
Publication Number
20070212410
Application Date
February 26, 2007
Publication Date
September 13, 2007
Inventor
Juan A Mantelle
Miami
FL, US
David P Kanios
Miami
FL, US
Agent
Foley And Lardner
DC, US
Assignee
Noven Pharmaceuticals
IPC
A61K 09/52
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