Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.

Title
Spiro[isobenzofuran-1,4-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4-piperidines
Application Number
11/183615
Publication Number
20060040964
Application Date
July 18, 2005
Publication Date
February 23, 2006
Inventor
Marlys Hammond
Salem
CT, US
Richard Louis Elliott
East Lyme
CT, US
Xiaozhang Zheng
Branford
CT, US
Jennifer Tran
Guilford
CT, US
Alan Hutchison
Madison
CT, US
Stephane De Lombaert
Madison
CT, US
James William Darrow
Wallingford
CT, US
Harry L Brielmann
Guilford
CT, US
Charles A Blum
Westbrook
CT, US
Rajagopal Bakthavatchalam
Branford
CT, US
Agent
Lawson & Weitzen
MA, US
IPC
C07D 491/10
A61K 31/4747
A61K 31/519
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