The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The invention also provides a method of isolating stem cells from adipose tissues. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

Title
Adipose-derived stem cells and lattices
Application Number
11/211114
Publication Number
20050282275
Application Date
August 24, 2005
Publication Date
December 22, 2005
Inventor
Min Zhu
Los Angeles
CA, US
Hermann Peter Lorenz
Los Angeles
CA, US
Prosper Benhaim
Los Angeles
CA, US
Marc H Hedrick
Encino
CA, US
J William Futrell
Pittsburgh
PA, US
Ramon Llull
Adam J Katz
Charlottesville
VA, US
Agent
Leydig Voit & Mayer
IL, US
Assignee
The Regents of the University of California
CA, US
University of Pittsburgh of the Commonwealth System of Higher Education
PA, US
IPC
C12N 05/08
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