The present invention relates to compounds of formula I: or a pharmaceutically acceptable salt or mixtures thereof that inhibit serine protease activity, particularly the activity of hepatitis C virus NS3-NS4A protease. As such, they act by interfering with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The invention further relates to compositions comprising these compounds either for ex vivo use or for administration to a patient suffering from HCV infection and to processes for preparing the compounds. The invention also relates to methods of treating an HCV infection in a patient by administering a composition comprising a compound of this invention. The invention further relates to processes for preparing these compounds.

Title
Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
Application Number
11/051977
Publication Number
20050215486
Application Date
February 4, 2005
Publication Date
September 29, 2005
Inventor
Janos Pitlik
Westborough
MA, US
Luc Farmer
Foxboro
MA, US
David Deininger
Arlington
MA, US
John Court
Littleton
MA, US
Kevin Cottrell
Cambridge
MA, US
Agent
Vertex Pharmaceuticals
MA, US
Agent
Michael C Badia
MA, US
IPC
C07D 43/02
C07K 05/04
A61K 38/04
A61K 38/05
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