The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides a adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.

Title
Adipose-derived stem cells and lattices
Application Number
10/845315
Publication Number
20050153442
Application Date
May 12, 2004
Publication Date
July 14, 2005
Inventor
Peter H Ashjian
New York
NY, US
Patricia Zuk
Venice
CA, US
Min Zhu
San Diego
CA, US
Hermann Peter Lorenz
Belmont
CA, US
Prosper Benhaim
Encino
CA, US
Marc H Hedrick
Encinitas
CA, US
J William Futrell
Pittsburgh
PA, US
Ramon Llull
Adam Katz
Charlottesville
VA, US
Agent
Mandel & Adriano
CA, US
IPC
C12N 05/08
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