Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I 1 or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.

Title
Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
Application Number
10/445817
Publication Number
20040009995
Application Date
May 28, 2003
Publication Date
January 15, 2004
Inventor
Hui Huang
Belle Mead
NJ, US
M Jonathan Rudolph
Exton
PA, US
Jinsheng Chen
Exton
PA, US
Mark Wall
Harleysville
PA, US
Sanath Meegalla
Boothwyn
PA, US
Joan Gushue
Collegeville
PA, US
Wenxi Pan
Glenmoore
PA, US
Maxwell D Cummings
Wayne
PA, US
Kenneth T Wilson
West Grove
PA, US
Shelley K Ballentine
Lansdale
PA, US
Jeremy M Travins
Newtown Square
PA, US
Heather Rae Hufnagel
Glenmoore
PA, US
Farah Ali
Exton
PA, US
Kristi Leonard
West Chester
PA, US
Ehab Khalil
West Chester
PA, US
Nalin Subasinghe
West Chester
PA, US
Agent
Sterne Kessler Goldstein & Fox Pllc
DC, US
Assignee
3 Dimensional Pharmaceuticals
IPC
A61K 31/381
A61K 31/4025
A61K 31/404
A61K 31/4184
A61K 31/427
A61K 31/428
A61K 31/4436
A61K 31/513
C07D 409/02
View Original Source