A microchip laboratory system and method provide fluid manipulations for a variety of applications, including sample injection for microchip chemical separations. The microchip is fabricated using standard photolithographic procedures and chemical wet etching, with the substrate and cover plate joined using direct bonding. Capillary, electrophoresis and electrochromatography are performed in channels formed in the substrate. Analytes are loaded into a four-way intersection of channels by electrokinetically pumping the analyte through the intersection, followed by switching of the potentials to force an analyte plug into the separation channel.

Title
Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
Application Number
10/426818
Publication Number
20030226753
Application Date
April 30, 2003
Publication Date
December 11, 2003
Inventor
J Michael Ramsey
Knoxville
TN, US
Agent
Dann Dorfman Herrell & Skillman
PA, US
IPC
G01N 27/27
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