The invention relates to novel nucleic acids encoding a mammalian PCADM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCADM-1 expression and/or production and activity of PCADM-1 polypeptide. Further, the invention relates to novel assays for the identification of DNA-binding proteins and the double-stranded oligonucleotide sequences that specifically bind with them. Finally, the invention relates to DNAZYMs or DNA enzymes which specifically bind PCADM-1 mRNA to inhibit PCADM-1 gene expression and thereby destroy tumor cells and tumor tissue.

Title
Prostate cancer-related compositions, methods, and kits based on DNA macroarray proteomics platforms
Application Number
10/140602
Publication Number
20030100033
Application Date
May 7, 2002
Publication Date
May 29, 2003
Inventor
Min Wang
Gulph Mills
PA, US
Youji Hu
Gulph Mills
PA, US
Mark Stearns
Villanova
PA, US
Agent
Morgan Lewis & Bockius
PA, US
IPC
C12N 05/06
C07K 14/47
C12P 21/02
C12N 09/00
C12N 15/09
C07H 21/04
G01N 33/574
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