The invention relates to novel nucleic acids encoding a mammalian PCAM-1 gene, and proteins encoded thereby, whose expression is increased in certain diseases, disorders, or conditions, including, but not limited to, prostate cancer. The invention further relates to methods of detecting and treating prostate cancer, comprising modulating or detecting PCAM-1 expression and/or production and activity of PCAM-1 polypeptide. Further, the invention relates to novel assays for the identification of DNA-binding proteins and the double-stranded oligonucleotide sequences that specifically bind with them.

Title
Prostate cancer-related compositions, methods, and kits based on DNA macroarray proteomics platforms
Application Number
9/813380
Publication Number
20020042062
Application Date
March 21, 2001
Publication Date
April 11, 2002
Inventor
Min Wang
Gulph Mills
PA, US
Youji Hu
Gulph Mills
PA, US
Mark Stearns
Villanova
PA, US
Agent
Morgan Lewis & Bockius
PA, US
IPC
C07K 14/47
C12N 05/06
C12P 21/02
C12N 09/00
C07H 21/04
G01N 33/574
C12Q 01/68
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