The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

Title
Method of preventing abuse of opioid dosage forms
Application Number
9/815162
Publication Number
20020004509
Application Date
March 22, 2001
Publication Date
January 10, 2002
Inventor
Robert D Colucci
Newtown
CT, US
Robert F Kaiko
Weston
CT, US
Philip J Palermo
Bethel
CT, US
Agent
Davidson Davidson & Kappel
NY, US
IPC
A61K 31/485
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