20010046673-A1 is referenced by 1 patents.

Methods and apparatus for detecting polynucleotide hybridization in luminescence-based assays. The methods may include (1) allele-specific hybridization, using luminescence detection, (2) allele-specific oligonucleotide ligation, using dye-labeled oligonucleotide ligation with luminescence resonance energy transfer (FRET) detection, and (3) allele-specific nucleotide incorporation, using primer extension with luminescence polarization (FP) detection. More specifically, the methods may include (1) locating a sample containing a nucleic acid material at an examination site, (2) illuminating the sample, (3) detecting light transmitted from the sample, and (4) determining the presence, absence, and/or identity of a nucleic acid target in the sample using the light transmitted from the sample.

Title
Methods and apparatus for detecting nucleic acid polymorphisms
Application Number
9/770720
Publication Number
20010046673
Application Date
January 25, 2001
Publication Date
November 29, 2001
Inventor
Peter R Panfili
Mountain View
CA, US
Yan Zhang Klompus
Redwood City
CA, US
Enal S Razvi
San Francisco
CA, US
Lev J Leytes
Palo Alto
CA, US
James S Richey
Palo Alto
CA, US
John C Owicki
Palo Alto
CA, US
Douglas N Modlin
Palo Alto
CA, US
Todd E French
Cupertino
CA, US
Agent
KOLISCH HARTWELL DICKINSON McCORMACK & HEUSER
OR, US
Assignee
LJL BioSystems
IPC
C12Q 01/68
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