Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.

Title
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
Application Number
1020017016850
Publication Number
1020020027379
Application Date
December 28, 2001
Publication Date
April 13, 2002
Inventor
Collins Michael Raymond
Wallace Michael Brennan
Varney Michael David
Thomas Christine
Teng Min
Tempczyk Russell Anna Maria
Reich Siegfried Heinz
Palmer Cynthia Louise
Luu Hiep The
Johnson Theodore Otto Jr
Johnson Michael David
Hua Ye
Cripps Stephan James
Braganza John F
Borchardt Allen J
Bender Steven Lee
Kania Robert Steven
Assignee
Agouron Pharmaceuticals
IPC
C07D 231/14
C07D 401/06
C07D 401/14