The invention relates in part to a method of reducing the abuse potential of an oral dosage form of an opioid analgesic, wherein an analgesically effective amount of an orally active opioid agonist is combined with an opioid antagonist into an oral dosage form which would require at least a two-step extraction process to be separated from the opioid agonist, the amount of opioid antagonist including being sufficient to counteract opioid effects if extracted together with the opioid agonist and administered parenterally.

Title
A method of preventing abuse of opioid dosage forms
Application Number
1020007006902
Publication Number
1020010033422
Application Date
June 21, 2000
Publication Date
April 25, 2001
Inventor
Palermo Philip
Assignee
Euro Celtique
IPC
A61K 31/485