1209654-A is referenced by 59 patents.

1,209,654. Pyrimidone nucleosides. MERCK & CO. Inc. 2 July, 1968 [3 July, 1967], No. 31574/68. Heading C2C. The novel [alpha]- and #-anomers of nucleosides of the formula -wherein L is a C 1-5 alkoxy, hydroxy, amino. C 1-5 alkyl substituted amino, M is as defined for L or H, C 1-5 alkyl, halogen or halogenated C 1-5 alkyl and either Y is H and Z is C 1-5 alkyl or Z is H and Y is C 1-5 alkyl, may be prepared by reacting a compound of the formula wherein each of R1, R11, and R111 is acyl and X is halogen, with a compound of the formula wherein V is H or C 1-5 alkyl, to form an intermediate of the formula wherein W is C 1-5 alkoxy or OH and subjecting this intermediate to (a) treatment with a solvent in the presence of a base, when W = OH, or (b) reaction with ammonia, C 1-5 alkylamine or di-(C 1-5 alkyl) amine when W=alkoxy.; The novel nucleosides demonstrate antiviral activity, are capable of inhibiting RNA synthesis, have favourable cytotoxicity characteristics and show resistance to the action of adenosine deaminase.

Title
Substituted ribofuranosyl pyrimidine nucleosides
Application Number
GB19680031574 19680702
Publication Number
1209654 (A)
Application Date
July 2, 1968
Publication Date
October 21, 1970
Inventor
Walton Edward
Assignee
Merck & Co
US
IPC
C07C 47/18
C07H 19/00
C07H 15/00
C07H 13/00
C07D 307/00
C07H 19/16
C07H 19/06
C07H 15/04
C07H 13/08
C07H 13/04
C07D 307/33
View Original Source Download PDF