1157586-A is referenced by 7 patents.

1,157,586. Amides; penicillins and cephalosporins. TOYO JOZO K.K. 14 Sept., 1967 [16 Sept., 1966], No. 41920/67. Headings C2A and C2C. Amides of the general formula R 2 CONHR 3 , wherein R 2 is an alkyl, cycloalkyl, alkenyl, cycloalkenyl, aryl, aralkyl, arylalkenyl or heterocyclic radical, which may be substituted by halogen, nitro, nitroso, amino, imino, hydroxy, cycloalkyl, alkoxy, aryloxy, alkoxycarbonyl, alkylcarbonyl, arylcarbonyl, alkylamide, arylamide, alkylthio, alkenyl, cycloalkenyl, alkenylthio, alkenylcarbonyl, aryl, aralkyl, arylalkenyl and heterocyclic radicals; ; and R 3 is an alkyl, cycloalkyl, aryl, aralkyl, amino, alkylamino, cycloalkylamino, arylamino, aralkylamino, alkylamide, cycloalkylamide, alkenylamide, arylamide, aralkylamide, cyclohexylcarboxyamide or cyclohexylamino radical which may be substituted by halogen, nitro, alkyl, alkoxy, carboxy, alkylcarbonyl, alkylamino, alkylamide, cycloalkyl, alkoxycarbonyl, cycloalkylamino, cycloalkylcarbonyl, cycloalkylamide, alkenyl, cycloalkenyl, alkenylcarbonyl, alkenylamino, alkenylamide, aryl, aralkyl, aralkenyl, arylamino, arylamide, arylcarbonyl, aralkylcarbonyl, aralkylamino, aralkylamide and heterocyclic radicals; are obtained by reacting a compound of the formula wherein R 1 is H or mono- or di-chloro-lower alkyl radical, with an acid of formula R 2 COOH to give a succinimide ester of the formula this succinimide ester then being reacted with a compound of formula R 3 NH 2 .; Examples are given for the production of the amides. Amides in which R 3 represents a penicillanic acid or cephalosporanic acid residue are obtained by reacting succinimide esters of Formula II with 6-aminopenicillanic acid or 7-aminocephalosporanic acid. Examples are given for the production of these amides.

Process for the manufacture of compounds having acid amide linkage
Application Number
GB19670041920 19670914
Publication Number
1157586 (A)
Application Date
September 14, 1967
Publication Date
July 9, 1969
Toyo Jozo
C07C 103/04
C07K 05/00
C07D 499/00
C07K 05/065
C07K 05/06
C07D 499/12
C07D 499/00
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