2650017-A2 cites 109 patents.

[en] The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, or antigen binding portions thereof, that specifically bind to integrin +-51 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies or antigen binding portions thereof are also provided. The disclosure also provides methods for treating various cancers using the anti-+-51 antibodies or antigen binding portions thereof described herein.

Title
[fr] Anticorps Alpha 5 - bêta 1 et leurs utilisations
[de] Alpha-5-beta-1-Antikörper und deren Verwendungen
[en] Alpha 5 - beta 1 antibodies and their uses
Application Number
EP20130159955
Publication Number
2650017 (A2)
Application Date
February 4, 2009
Publication Date
October 16, 2013
Inventor
YAMANAKA MARK
US
SPROUL TIM W
US
YANG LAN
US
TOY KRISTOPHER
US
TANAMACHI DAWN
US
CHEN HAIBIN
US
DEVAUX BRIGITTE
US
HUANG HAICHUN
US
BRAMS PETER
US
WICKMAN GRANT
CA
WANG JIANYING
US
NORTH MICHAEL AIDAN
US
LI GANG
US
JIANG XIN
US
HU LOWE DANA DAN
US
CASPERSON GERALD FRIES
US
BENDER STEVEN LEE
US
Assignee
PFIZER
US
SQUIBB BRISTOL MYERS CO
US
IPC
C07K 16/28
A61P 35/00
A61K 39/395
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