The invention relates to the use of cells from cell lines, which are derived from early embryonic stages, for the donor-specific increase in transplantation tolerance and for repairing damaged tissue. Areas of application of the invention include the field of medicine and the pharmaceutical industry. The aim of the invention is to produce a donor-specific immunotolerance in order to prevent a rejection of the transplanted tissue due to an immune response and thus to be able to limit the administration of immunosuppressives. In order to produce a donor-specific immunotolerance, embryonic stem cell-like cell lines (ECL) are obtained from blastocysts and are transfected with genetic material of the donor, which codes for the MHC haplotypes.; The cells produced in such a manner are administered to the recipient before the transplantation for producing an immunotolerance against the tissue to be transplanted or for regenerating already damaged tissue.

Title
Use of cells derived from embryonic stem cells for increasing transplantation tolerance and for repairing damaged tissue
Application Number
EP20010995556 20011204
Publication Number
1341915 (A1)
Application Date
December 4, 2001
Publication Date
September 10, 2003
Inventor
Lin Xiongbin
DE
Ganten Detlev
DE
Faendrich Fred
DE
Chai Giuxuan
US
Binas Bert
US
Bader Michael
DE
Assignee
Max Delbrueck Centrum
DE
IPC
C12N 05/10
C07K 14/74
A61K 48/00
A01K 67/027
C12N 15/12
C12N 15/85
C12N 15/12
C12N 05/10
C12N 05/08
C12N 05/06
C07K 14/435
A61P 43/00
A61P 37/00
A61P 09/00
A61P 01/00
A61K 48/00
A61K 39/00
A61K 35/48
A01K 67/027
C12N 15/09
C12N 15/85
C12N 15/12
C12N 05/10
C12N 05/08
C12N 05/06
C07K 14/74
A61P 43/00
A61P 37/06
A61P 09/04
A61P 01/16
A61K 48/00
A61K 39/00
A61K 35/48
A01K 67/027
C12N 15/09
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