1221444-A1 is referenced by 32 patents and cites 22 patents.

The present invention provides a preventive or therapeutic agent for diabetes mellitus and diabetic complications, which is a new type based on an adenosine A2 receptor antagonist action. That is, it provides a novel condensed imidazole compound which has an adenosine A2 receptor antagonist action, is effective for preventing or treating diabetes mellitus and diabetic complications, and is represented by the formula (I): (wherein R represents e.g. an amino group which may be substituted with an alkyl group; R represents e.g. hydrogen atom, an alkyl group, a cycloalkyl group or an alkyl group, alkenyl group or alkynyl group which may be substituted with hydrox etc.; R represents e.g. an optionally substituted alkyl group, alkenyl group, alkynyl group, aryl group, heteroaryl group, pyridinone group, pyrimidinone group or piperadinone group; Ar represents e.g. an optionally substituted aryl or heteroaryl group; and Q and W are the same as or different from each other and each represents N or CH), a pharmacologically acceptable salt or hydrates thereof.

Title
Fused imidazole compounds and remedies for diabetes mellitus
Application Number
EP20000940909 20000630
Publication Number
1221444 (A1)
Application Date
June 30, 2000
Publication Date
July 10, 2002
Inventor
Haga Toyokazu
JP
Hayashi Kenji
JP
Shimizu Toshikazu
JP
Ozeki Naoki
JP
Akamatsu Hiroshi
JP
Shimomura Naoyuki
JP
Kawata Tsutomu
JP
Tanaka Isao
JP
Kobayashi Seiichi
US
Murakami Manabu
JP
Nagaoka Junsaku
JP
Minami Hiroe
JP
Ohashi Kaya
JP
Yasuda Nobuyuki
JP
Horizoe Tatsuo
JP
Inoue Takashi
JP
Watanabe Nobuhisa
JP
Yoshikawa Seiji
JP
Harada Hitoshi
JP
Asano Osamu
JP
Assignee
Eisai
JP
IPC
C07D 487/04
C07D 473/40
C07D 473/18
C07D 471/08
C07D 471/04
C07D 239/48
C07D 235/18
C07D 213/75
C07D 213/73
A61P 43/00
A61P 03/10
A61K 31/522
A61K 31/52
A61K 31/437
C07D 473/34
C07D 473/00
C07D 471/00
A61P 43/00
A61P 03/00
C07D 473/40
C07D 473/34
C07D 473/00
C07D 471/04
A61P 43/00
A61P 03/10
View Original Source Download PDF